Comparison of the Effect of Six Weeks of Aerobic and Resistance Training on CK, PGC-1 and TNF-α in Cardiac Tissue of Wistar Diabetic Rats

Introduction: Diabetes causes inflammation and destruction of heart cells in people. The aim of this study was to compare the effect of six weeks of aerobic and resistance training on TNF-α, PGC-1 and CK in the heart tissue of male Wistar diabetic rats. Methods: The research method was experimental and fundamental. 25 rats weighing approximately 200 to 250 grams and the average age between 10 to 12 weeks were purchased and divided into 5 groups: aerobic training (N = 6), resistance training (N = 6), sham (N = 6), control (N = 4), and healthy (N = 3), were divided. Induction of diabetes was performed by injecting a single dose of STZ dissolved in sodium citrate buffer intraperitoneally. Aerobic and resistance training program was performed for 6 weeks and five days a week. 48 hours after the last training session, TNF-α, PGC-1 and CK variables were measured by isolating rat heart tissue. Statistical data were analyzed by one-way analysis of variance and Scheffe post hoc test at a significance level of 0.05. Results:  Results showed that six weeks of aerobic and resistance training had a significant effect on the reduction of TNF-α and CK in the heart tissue of male Wistar diabetic rats (P<0.05). Also, six weeks of aerobic and resistance training had a significant effect on the increase of PGC-1 in the heart tissue of male Wistar diabetic rats (P<0.05). There was no significant difference between the effect of six weeks of aerobic and resistance training on TNF-α, PGC-1 and CK in the heart tissue of male Wistar diabetic rats (P<0.05). Conclusion:  The results indicate that aerobic or resistance training may be effective in modulating inflammatory factors and genes involved in the insulin signaling pathway of diabetic rats.